1. NU2058

NU2058  (Synonyms: O6-(Cyclohexylmethyl)guanine)

Cat. No.: HY-19316 Purity: 98.78%
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NU2058 (O6-(Cyclohexylmethyl)guanine) is a potent, competitive and guanine-based CDK inhibitor with IC50s of 17 μM and 26 μM for CDK2 and CDK1. NU2058 has anti-cancer activity.

For research use only. We do not sell to patients.

NU2058 Chemical Structure

NU2058 Chemical Structure

CAS No. : 161058-83-9

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 62 In-stock
Solution
10 mM * 1 mL in DMSO USD 62 In-stock
Solid
5 mg USD 55 In-stock
10 mg USD 96 In-stock
50 mg USD 256 In-stock
100 mg USD 400 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

NU2058 (O6-(Cyclohexylmethyl)guanine) is a potent, competitive and guanine-based CDK inhibitor with IC50s of 17 μM and 26 μM for CDK2 and CDK1. NU2058 has anti-cancer activity.

In Vitro

NU2058 (O6-(Cyclohexylmethyl)guanine) is a competitive inhibitor of CDK2 with respect to ATP (Ki value CDK2, 12 μM) that binds in the ATP binding pocket in a different orientation from other purine-based inhibitors, including olomoucine and roscovotine. NU2058 is the lead compound in a structure-based drug discovery program to develop more potent and selective CDK inhibitors.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

247.30

Formula

C12H17N5O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC(OCC2CCCCC2)=C3NC=NC3=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (129.40 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0437 mL 20.2184 mL 40.4367 mL
5 mM 0.8087 mL 4.0437 mL 8.0873 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0437 mL 20.2184 mL 40.4367 mL 101.0918 mL
5 mM 0.8087 mL 4.0437 mL 8.0873 mL 20.2184 mL
10 mM 0.4044 mL 2.0218 mL 4.0437 mL 10.1092 mL
15 mM 0.2696 mL 1.3479 mL 2.6958 mL 6.7395 mL
20 mM 0.2022 mL 1.0109 mL 2.0218 mL 5.0546 mL
25 mM 0.1617 mL 0.8087 mL 1.6175 mL 4.0437 mL
30 mM 0.1348 mL 0.6739 mL 1.3479 mL 3.3697 mL
40 mM 0.1011 mL 0.5055 mL 1.0109 mL 2.5273 mL
50 mM 0.0809 mL 0.4044 mL 0.8087 mL 2.0218 mL
60 mM 0.0674 mL 0.3370 mL 0.6739 mL 1.6849 mL
80 mM 0.0505 mL 0.2527 mL 0.5055 mL 1.2636 mL
100 mM 0.0404 mL 0.2022 mL 0.4044 mL 1.0109 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
NU2058
Cat. No.:
HY-19316
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