1. Protein Tyrosine Kinase/RTK
  2. Btk

ONO-4059 (Synonyms: GS-4059)

Cat. No.: HY-15771 Purity: 98.31%
Data Sheet SDS Handling Instructions

ONO-4059 is a highly selective, orally bioavailable BTK inhibitor with a potency (IC50) of 2.2 nM.

For research use only. We do not sell to patients.
ONO-4059 Chemical Structure

ONO-4059 Chemical Structure

CAS No. : 1351636-18-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $105 In-stock
5 mg $95 In-stock
10 mg $150 In-stock
25 mg $280 In-stock
50 mg $500 In-stock
100 mg $800 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Other Forms of ONO-4059:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


ONO-4059 is a highly selective, orally bioavailable BTK inhibitor with a potency (IC50) of 2.2 nM. target: BTK IC:50 2.2 nM [1] In vitro: The compound covalently bonds to BTK, inhibiting BCR signaling and B-cell proliferation and activation. [1] NO/GS-4059 induced durable responses in relapsed/refractory B-cell malignancies without significant toxicities.[2] In vivo: ONO-4059 demonstrated therapeutic efficacy in a mouse arthritis model, and based on its anti-proliferative activity in B-cells. [1]

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT01659255 Gilead Sciences|Ono Pharmaceutical Co. Ltd Non Hodgkins Lymphoma|Chronic Lymphocytic Leukaemia August 2012 Phase 1
NCT02626026 Gilead Sciences Rheumatoid Arthritis January 2016 Phase 1
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Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.2003 mL 11.0016 mL 22.0032 mL
5 mM 0.4401 mL 2.2003 mL 4.4006 mL
10 mM 0.2200 mL 1.1002 mL 2.2003 mL
Molecular Weight






Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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