1. Cell Cycle/DNA Damage
  2. CDK

THZ1-R 

Cat. No.: HY-19988 Purity: 98.30%
Data Sheet SDS Handling Instructions

THZ1-R is an inhibitor of CDK7, with an IC50 of 146 nM.

For research use only. We do not sell to patients.
THZ1-R Chemical Structure

THZ1-R Chemical Structure

CAS No. : 1621523-07-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 525 In-stock
1 mg USD 180 In-stock
5 mg USD 420 In-stock
10 mg USD 660 In-stock
50 mg USD 1980 In-stock
100 mg USD 2760 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

THZ1-R is an inhibitor of CDK7, with an IC50 of 146 nM.

IC50 & Target

IC50: 146 nM (CDK7)[1]

In Vitro

THZ1-R shows lower affinity at CDK7 than THZ1, with IC50 of 146 nM[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.7603 mL 8.8017 mL 17.6035 mL
5 mM 0.3521 mL 1.7603 mL 3.5207 mL
10 mM 0.1760 mL 0.8802 mL 1.7603 mL
Please refer to the solubility information to select the appropriate solvent.
Cell Assay
[1]

THZ1-R is dissolved in DMSO.

Cells are seeded in 384-well microplates at 15% confluency in medium with 5% FBS and penicillin/streptavidin. Cells are treated with THZ1 or DMSO for 72 hrs and cell viability is determined using resazurin. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

568.07

Formula

C₃₁H₃₀ClN₇O₂

CAS No.

1621523-07-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
THZ1-R
Cat. No.:
HY-19988
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