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Signaling Pathway

MG-101

HY-18964

(Calpain inhibitor I; ALLN)

MG-101

MG-101 Chemical Structure

MG-101 is a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).

Size Price Stock Quantity
10 mM * 1 mL in DMSO $86 In-stock
5 mg $78 In-stock
10 mg $120 In-stock
50 mg $400 In-stock
100 mg $650 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €84 In-stock
5 mg €76 In-stock
10 mg €118 In-stock
50 mg €392 In-stock
100 mg €637 In-stock
200 mg Get quote
500 mg Get quote

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Product name: MG-101
Cat. No.: HY-18964

MG-101 Data Sheet

  • Pdf Version Network Version

    DataSheet

Related Compound Libraries

Biological Activity of MG-101

MG-101 is a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).
IC50 value: 150 nM (Ki)
Target: cysteine protease
in vitro: MG-101 is a calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. At 10-100 μM MG-101 dose-dependently prevents the degradation of IκBα and IκBβ by the ubiquitin-proteasome complex, which blocks activation of NFκB and the production of TNF and IL-1β, suggesting a potential therapeutic effect for inflammatory diseases.2 At 10 μM, MG-101 can inhibit nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. In HCT116 cells, MG-101 decreases cell viability and tumor growth, and induces apoptosis response through Bax translocation from cytosol to mitochondria. [1]
in vivo: In mice bearing HCT116 xenografts, MG-101 (10 mg/kg i.p.) inhibits colon tumor formation. [1]

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 383.53 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C20H37N3O4
CAS No 110044-82-1
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.6074 mL 13.0368 mL 26.0736 mL
5 mM 0.5215 mL 2.6074 mL 5.2147 mL
10 mM 0.2607 mL 1.3037 mL 2.6074 mL

References on MG-101

Inhibitor Kit

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