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Capadenoson Chemical Structure
|Product name: Capadenoson|
|Cat. No.: HY-14917|
Capadenoson (BAY 68-4986) is a new adenosine A1 receptor agonist.
Target: adenosine A1 receptor
Studies showed that long-term therapy with Capadenoson improves phosphorylation and total protein level of PGC-1α in LV myocardium of HF dogs. Clinical trial found that in patients with stable angina Capadenoson lowers exercise HR at comparable maximum workload, which is associated with improved total exercise time and prolongation of time to ischaemia.
|M.Wt||520.03||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
10 mM in DMSO
|1 mg||5 mg||10 mg|
|1 mM||1.9230 mL||9.6148 mL||19.2297 mL|
|5 mM||0.3846 mL||1.9230 mL||3.8459 mL|
|10 mM||0.1923 mL||0.9615 mL||1.9230 mL|
|Product Name||Sponsor Only||Condition||Start Date||End Date||Phase||Last Change Date|
|Capadenoson||Bayer AG||Angina||31-MAR-08||01-NOV-08||Phase 2||12-SEP-13|
|Bayer AG||Atrial fibrillation||23-JAN-08||31-DEC-08||Phase 2||12-JUN-13|
. Ramesh C. Gupta, et al. Long-term therapy with the partial adenosine A1-receptor agnosit capadenoson, improves peroxisome proliferator-activated receptor coactivator-1α phosphorylation and protein expression in left ventricular myocardium of dogs with chronic heart failure. J Am Coll Cardiol. 2013;61(10_S).
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