1. GPCR/G Protein
  2. Guanylate Cyclase

(4-Acetamidocyclohexyl) nitrate (Synonyms: BM121307)

Cat. No.: HY-100295
Handling Instructions

BM121307 is a guanylate cyclase activator that was in phase I development for the treatment of ischaemic heart disorders. The research has been discontinued.

For research use only. We do not sell to patients.

(4-Acetamidocyclohexyl) nitrate Chemical Structure

(4-Acetamidocyclohexyl) nitrate Chemical Structure

CAS No. : 137213-91-3

Size Price Stock
1 mg USD 375 Get quote
5 mg USD 601 Get quote
10 mg USD 961 Get quote

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


BM121307 is a guanylate cyclase activator that was in phase I development for the treatment of ischaemic heart disorders. The research has been discontinued.

In Vivo

The elimination of BM121307 and its metabolites via urine and feces amount to 76.5% after oral application, and to 80.7% of the applied dose after intravenous application. The major amount of radioactivity is eliminated via urine (69.4% and 73.6% of the dose, respectively), whereas the fecal elimination is found to be negligible. Investigations of the urinary samples show that the drug is metabolized to a high percentage trans-N-(4-Hydroxycyclohexyl) acetamide is the main metabolite; 73% of the radioactive compounds (after p.o.-administration and 69% after intravenous application could be identified as the alcohol of BM121307; the amounts of the drug totaled 9% and 13%, respectively[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9454 mL 24.7268 mL 49.4535 mL
5 mM 0.9891 mL 4.9454 mL 9.8907 mL
10 mM 0.4945 mL 2.4727 mL 4.9454 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration


The biotransformation of BM121307 in the dog is examined after oral and intravenous administration. For that purpose, the organic nitrate is synthesized as radioactive [14C]- and as [13C]-labeled compounds. The defined isotopic mixture is administered to the dogs. Within the examined period of 168 h, the elimination of BM121307 is measured[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







CC(N[[email protected]@H]1CC[[email protected]@H](O[N+]([O-])=O)CC1)=O


Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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Product Name:
(4-Acetamidocyclohexyl) nitrate
Cat. No.:

(4-Acetamidocyclohexyl) nitrate

Cat. No.: HY-100295