1. GPCR/G Protein
  2. Guanylate Cyclase
  3. (4-Acetamidocyclohexyl) nitrate

(4-Acetamidocyclohexyl) nitrate (Synonyms: BM121307)

Cat. No.: HY-100295
Handling Instructions

(4-Acetamidocyclohexyl) nitrate (BM121307) is a guanylate cyclase activator.

For research use only. We do not sell to patients.

(4-Acetamidocyclohexyl) nitrate Chemical Structure

(4-Acetamidocyclohexyl) nitrate Chemical Structure

CAS No. : 137213-91-3

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(4-Acetamidocyclohexyl) nitrate (BM121307) is a guanylate cyclase activator.

In Vivo

The elimination of BM121307 and its metabolites via urine and feces amount to 76.5% after oral application, and to 80.7% of the applied dose after intravenous application. The major amount of radioactivity is eliminated via urine (69.4% and 73.6% of the dose, respectively), whereas the fecal elimination is found to be negligible. Investigations of the urinary samples show that the drug is metabolized to a high percentage trans-N-(4-Hydroxycyclohexyl) acetamide is the main metabolite; 73% of the radioactive compounds (after p.o.-administration and 69% after intravenous application could be identified as the alcohol of BM121307; the amounts of the drug totaled 9% and 13%, respectively[1].

Molecular Weight







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Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Animal Administration


The biotransformation of BM121307 in the dog is examined after oral and intravenous administration. For that purpose, the organic nitrate is synthesized as radioactive [14C]- and as [13C]-labeled compounds. The defined isotopic mixture is administered to the dogs. Within the examined period of 168 h, the elimination of BM121307 is measured[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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