1. GPCR/G Protein
  2. Guanylate Cyclase

(4-Acetamidocyclohexyl) nitrate (Synonyms: BM121307)

Cat. No.: HY-100295
Handling Instructions

BM121307 is a guanylate cyclase activator that was in phase I development for the treatment of ischaemic heart disorders. The research has been discontinued.

For research use only. We do not sell to patients.

(4-Acetamidocyclohexyl) nitrate Chemical Structure

(4-Acetamidocyclohexyl) nitrate Chemical Structure

CAS No. : 137213-91-3

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1 mg USD 375 Get quote
5 mg USD 601 Get quote
10 mg USD 961 Get quote

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

BM121307 is a guanylate cyclase activator that was in phase I development for the treatment of ischaemic heart disorders. The research has been discontinued.

In Vivo

The elimination of BM121307 and its metabolites via urine and feces amount to 76.5% after oral application, and to 80.7% of the applied dose after intravenous application. The major amount of radioactivity is eliminated via urine (69.4% and 73.6% of the dose, respectively), whereas the fecal elimination is found to be negligible. Investigations of the urinary samples show that the drug is metabolized to a high percentage trans-N-(4-Hydroxycyclohexyl) acetamide is the main metabolite; 73% of the radioactive compounds (after p.o.-administration and 69% after intravenous application could be identified as the alcohol of BM121307; the amounts of the drug totaled 9% and 13%, respectively[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9454 mL 24.7268 mL 49.4535 mL
5 mM 0.9891 mL 4.9454 mL 9.8907 mL
10 mM 0.4945 mL 2.4727 mL 4.9454 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Dogs[1]

The biotransformation of BM121307 in the dog is examined after oral and intravenous administration. For that purpose, the organic nitrate is synthesized as radioactive [14C]- and as [13C]-labeled compounds. The defined isotopic mixture is administered to the dogs. Within the examined period of 168 h, the elimination of BM121307 is measured[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

202.21

Formula

C₈H₁₄N₂O₄

CAS No.

137213-91-3

SMILES

CC(N[[email protected]@H]1CC[[email protected]@H](O[N+]([O-])=O)CC1)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
(4-Acetamidocyclohexyl) nitrate
Cat. No.:
HY-100295
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(4-Acetamidocyclohexyl) nitrate

Cat. No.: HY-100295