1. Anti-infection
  2. Bacterial
  3. BO3482


Cat. No.: HY-U00255
Handling Instructions

BO3482 has Antimicrobial activity and can inhibit the growth of methicillin-resistant Staphylococci (MRS) with an MIC90 of 6.25 mg/mL.

For research use only. We do not sell to patients.

BO3482 Chemical Structure

BO3482 Chemical Structure

CAS No. : 198013-53-5

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BO3482 has Antimicrobial activity and can inhibit the growth of methicillin-resistant Staphylococci (MRS) with an MIC90 of 6.25 mg/mL.

IC50 & Target

MIC90: 6.25 μg/mL (Staphylococci)[1]

In Vivo

In the thigh infection model with a homogeneous MRSA strain, the bacterial counts in tissues treated with BO3482-cilastatin are significantly reduced in a dose-dependent manner compare with the counts in those treat with vancomycin and imipenem-cilastatin[1].

Molecular Weight







OC(C1=C(SC(N(C)CCO)=S)[[email protected]](C)[[email protected]@]([[email protected]@]2([H])[[email protected]](O)C)([H])N1C2=O)=O.[Na]


Room temperature in continental US; may vary elsewhere


Please store the product under the recommended conditions in the Certificate of Analysis.

Animal Administration

In the thigh infection model, four immunosuppressed mice are used per group. An overnight culture of MRSA BB6294 in tryptic soy broth is washed and resuspended in fresh tryptic soy broth. Of this suspension, 0.1 mL is injected into the right thighs of slightly anesthetized mice. The mice receive two doses of drug subcutaneously 2 and 6 h after injection of the test organisms by the following treatment regimens: 10, 20,or 40 mg of BO3482 with 40 mg of cilastatin per kg per dose; 10, 20, or 40 mg of vancomycin per kg per dose; or 40 mg of imipenem with 40 mg of cilastatin per kg per dose. Four hours after the last treatment, the thigh muscles are removed and immediately homogenized in ice-cold 0.9% NaCl with a tissue homogenizer[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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