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Betanin 

Cat. No.: HY-112578
Handling Instructions

Betanin has potent antioxidative and anti-inflammatory activity could inhibit peroxynitrite (ONOO-), with an IC50 of 19.2 μM.

For research use only. We do not sell to patients.

Betanin Chemical Structure

Betanin Chemical Structure

CAS No. : 7659-95-2

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Description

Betanin has potent antioxidative and anti-inflammatory activity could inhibit peroxynitrite (ONOO-), with an IC50 of 19.2 μM.

IC50 & Target

IC50: 19.2 μM (ONOO-)[1].

In Vitro

Betanin is a representative constituent of red beetroot betacyanins, could inhibit peroxynitrite (ONOO-), with an IC50 of 19.2 μM[1]. Betanin also has anti-inflammatory, anti-proliferative effects, nephroprotective activity, cardioprotective activity, strong, antioxidant and angiotensin converting enzyme (ACE) inhibitory activity[2]. Another study is also indicated the protective effect of Betanin against high glucose induced rat renal epithelial cell fibrosis and matrix accumulation, major features of diabetic nephropathy (DN)[2].

In Vivo

Betanin can inhibit the fructose-induced diabetic cardiac fibrosis and paraquat induced acute kidney toxicity[2]. The co-administration of Betanin (20 mg/kg b.w.) to diabetic rats prevent significantly the raise of glucose level and also reverse the levels of insulin compared with untreated diabetic rats. Interestingly diabetic rats treated with Betanin (20 mg/kg b.w.) and glibenclamide portray the significant changes in the body weight compared to diabetic control. HbA1c levels significantly increases in diabetic rats and when treated with Betanin as well as glibenclamide. Treatment with Betanin as well as glibenlamide to STZ-NA induces diabetic rat’s elicit significant decreases in those levels when compared with diabetic control rats[3].

Solvent & Solubility
In Vitro: 

H2O : 150 mg/mL (272.49 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8166 mL 9.0831 mL 18.1663 mL
5 mM 0.3633 mL 1.8166 mL 3.6333 mL
10 mM 0.1817 mL 0.9083 mL 1.8166 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Betanin is dissolved in water[2].

References
Animal Administration
[3]

Rats[3]
Healthy adult Male albino Wistar strain (Rattus norvegicus, 90-120 days of age) are used in the current study. After the successful induction of experimental diabetes, the rats are divided into four groups each comprising a minimum of six rats a total of 30 rats (18 diabetic surviving rats, 12 normal rats). Betanin is administered via oral intubation to the experimental rats using a gavage needle daily for a period of 30 days. Group 1: Normal Control rats. Group 2: Rats treated with Betanin (20 mg/kg b.w.) alone. Group 3: Diabetic Control rats. Group 4: Rats treated with STZ-NA by i.p. and Betanin (20 mg/kg b.w.). Group 5: Rats treated with STZ-NA by i.p. and glibenclamide (600 μg/kg b.w.)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

550.47

Formula

C₂₄H₂₆N₂O₁₃

CAS No.

7659-95-2

SMILES

OC([[email protected]@H]1CC(/C=C/N2C3=CC(O)=C(O[[email protected]@H]4O[[email protected]@H]([[email protected]@H](O)[[email protected]](O)[[email protected]]4O)CO)C=C3C[[email protected]]2C(O)=O)=CC(C(O)=O)=N1)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Betanin
Cat. No.:
HY-112578
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Betanin

Cat. No.: HY-112578