N-Methylmoranoline
N-Methylmoranoline (MOR 14) is an α-glucosidase inhibitor.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.0%
- CAS. Nr.: 69567-10-8
- Formel: C7H15NO4
- Molecular Weight:177.20
-
Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MOLT-4 | CC50 |
>100 mg/mL
Compound: 2
|
Concentration giving 50% inhibition of growth of mock-infected MOLT-4 cells
Concentration giving 50% inhibition of growth of mock-infected MOLT-4 cells
|
[PMID: 7608901] |
| MOLT-4 | EC50 |
100 mg/mL
Compound: 2
|
Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MOLT-4 cells
Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MOLT-4 cells
|
[PMID: 7608901] |
| MT4 | CC50 |
>100 mg/mL
Compound: 2
|
Concentration giving 50% inhibition of growth of mock-infected MT-4 cells
Concentration giving 50% inhibition of growth of mock-infected MT-4 cells
|
[PMID: 7608901] |
| MT4 | EC50 |
69 mg/mL
Compound: 2
|
Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MT-4 cells
Concentration giving 50% inhibition of HIV-1 induced cytopathogenicity in MT-4 cells
|
[PMID: 7608901] |
In Vitro
N-Methylmoranoline dose-dependently decreases the α-1,6-glucosidase activity in rabbit heart extract. The myocardial uptake of a considerable amount of N-Methylmoranoline is sufficient to fully inhibit alpha-1,6-glucosidase. Preischemic treatment with 25, 50, and 100 mg/kg of N-Methylmoranoline dose-dependently reduces the infarct size without altering the blood pressure or heart rate[1]. MOR-14 significantly increases levels of PKC-ε in the particulate fraction at 20 and 30 min of ischaemia and in the cytosolic fraction at 30 min of ischaemia[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 69567-10-8
-
Appearance Solid
-
Molecular Weight 177.20
-
Formel C7H15NO4
-
Color White to off-white
-
SMILES
O[C@@H]1[C@@H](CO)N(C)C[C@H](O)[C@H]1O
-
Synonyms
MOR 14; N-Methyl-1-deoxynojirimycin; N-Methylmoranolin
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
-
Data Sheet (274 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
Verweise
[1]. Arai M, et al. N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly reduced infarct size in rabbit hearts. Circulation. 1998 Apr 7;97(13):1290-7. [Content Brief]
[2]. Arai M, et al. Role of protein kinase C in the reduction of infarct size by N-methyl-1-deoxynojirimycin, an alpha-1,6-glucosidase inhibitor. Br J Pharmacol. 2001 Jul;133(5):635-42. [Content Brief]
[3]. Nishida Y, et al. N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction. Heart Vessels. 2000;15(6):268-73. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
N-Methylmoranoline Related Classifications
HY-U00090 Related Classifications
Powered by Bioz