Juncaceae

Effusol, a phenolic constituent from Juncus effuses, exhibits potent scavenging activity for DPPH and ABTS radicals, with IC₅₀ values of 79 μM and 2.73 μM, respectively. Effusol rescues CA1 LTP attenuated by corticosterone, defending the hippocampal function against stress-induced cognitive decline.

Dehydroeffusol is a phenanthrene from medicinal herb Juncus effuses. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. It shows very low toxicity.

1-Methyleffusol is a natural phenolic compound.

Juncatrin A is a dihydrophenanthrene compound that can be naturally extracted from the whole plant methanol extract of Juncus atratus Krock. (a plant of the Juncaceae family, Juncus genus). Juncatrin A exhibits only weak antiproliferative activity against HeLa human cervical cancer cells (55.60% inhibition at 30 μM). Juncatrin A can be used in the research of anticancer natural drug precursors and active components of Juncus plants.

1,6-Dimethyl-4,5-dihydropyrene-2,7-diol is a natural phenolic compound.

Juncuenin A is a natural phenolic compound.

Effususol A is a natural phenolic compound.

9,10-Didehydroeffususol A is a natural phenolic compound.

Jinflexin A is a natural phenolic compound.

1,6-Dimethyl-5-vinyl-9,10-dihydrophenanthren-2-ol is a natural phenolic compound.

Dehydrojuncuenins A is a natural phenolic compound.

Jinflexin D is a potential antibacterial agent, without inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA). Jinflexin D is a dimeric phenanthrene natural product with a unique seven-membered ring system, naturally extracted from the methanol extract of the roots of Juncus inflexus (a plant of the Juncaceae family).

Juncatrin B is a type of dihydrophenanthrene compound. Juncatrin B exhibits inhibitory activity against both Methicillin (HY-121544)-sensitive Staphylococcus aureus (MSSA) and Methicillin-resistant Staphylococcus aureus (MRSA). Juncatrin B can inhibit the formation of biofilms in MSSA and MRSA. Juncatrin B has no significant activity against Gram-negative bacteria. Juncatrin B can be used in the research of anti-Staphylococcus aureus.

2-Methoxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthren-7-ol (Compound 1) is a 9,10-dihydrophenanthrene derivative. 2-Methoxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthren-7-ol can be isolated from Juncus compressus. 2-Methoxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthren-7-ol exhibits anticancer activity against cervical and ovarian cancers. 2-Methoxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthren-7-ol can be used for HSV-2 virus research.

Juncusol 2-O-glucoside is an active compound.

Juncutol is a potent inducible nitric oxide synthase (iNOS) inhibitor. Juncutol decreases the LPS (HY-D1056)-stimulated iNOS protein expression.

Dehydrojuncuenin B is a phenanthrenoid compound, which can be isolated from the underground parts of Juncus setchuenensis.

Juncuenin D induces caspase-3-mediated cytotoxicity in HT22 cells. Juncuenin D also has anti-bacterial activity against MRSA strains. Juncuenin D can be isolated from J. effusus.

2,7-Dihydroxy-1,6-dimethylpyrene is a pyrene that can be isolated from the wetland plant Juncus acutus and inhibits growth of the freshwater green alga Selenastrum capricornutum.

Juncusol 7-O-glucoside is a natural product.