1. Anti-infection
  2. HCV
  3. PSI-352938

PSI-352938 (Synonyms: PSI-938)

Cat. No.: HY-15231
Handling Instructions

PSI-352938 (PSI-938) is a hepatitis C virus (HCV) nucleotide inhibitor.

For research use only. We do not sell to patients.

PSI-352938 Chemical Structure

PSI-352938 Chemical Structure

CAS No. : 1231747-17-3

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PSI-352938 (PSI-938) is a hepatitis C virus (HCV) nucleotide inhibitor[1].

IC50 & Target


In Vitro

PSI-352938 (PSI-938) and PSI-353661 inhibit HCV genotype (GT) 1b replicon replication with 50% effective concentrations (EC50s) of 0.13±0.076 μM and 3.0±1.4 nM, respectively, and are similarly active against GT 1a and 2a replicons and infectious viruses. Metabolism of PSI-352938 and PSI-353661 generates the same 5′-triphosphate metabolite, PSI-352666, which is similarly active against NS5B polymerases from GT 1 to 4[1]. PSI-352938 (PSI-938) is a novel cyclic phosphate prodrug of β-D-2′-deoxy-2′-α-fluoro-2′-β-C-methylguanosine 5′-monophosphate that has potent activity against HCV. PSI-352938 (PSI-938) has similar activity against genotype 1a, 1b, and 2a replicons, with EC50s ranging from 0.13 to 0.20 μM and EC90 values ranging from 0.35 to 0.74 μM. PSI-352938 (PSI-938) also effectively inhibits HCV replication in the infectious virus assays: the EC50 and EC90 values are 0.28±0.083 μM and 0.63±0.018 μM, respectively, against the H77 infectious virus and 0.39±0.31 μM and 1.16±0.64 μM, respectively, against the JFH-1 infectious virus. In contrast, PSI-352938 is not active against HBV or HIV up to the highest concentration tested (EC50>100 μM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight





Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Cell Assay

GT 1a, 1b, and 2a replicon cells are cultured in the presence of G418 (0.75 mg/mL for GT 1a, 0.25 mg/mL for GT 1b and 2a) and increasing concentrations of PSI-352938 (PSI-938) or PSI-353661 starting at their respective EC50 or EC90. As a no-compound control, replicon cells are maintained in parallel in the equivalent percent volume (0.2%) of DMSO. Cells are passaged whenever they reach ∼80% confluence and replenished with G418 medium containing fresh compound. At various passages, cells are tested for sensitivity to PSI-352938 (PSI-938) and PSI-353661. For each assay, 3-fold dilutions of test compound are added to cells in duplicate and incubated at 37°C in a humidified 5% CO2 atmosphere for 4 days. Inhibition of HCV replicon RNA replication is determined by real-time PCR (RT-PCR) using primers that anneal to the 5′ untranslated region or by measuring the levels of luminescence expressed via the firefly or Renilla luciferase reporter gene using the Bright-Glo or Renilla-Glo reagent, respectively. EC50 and EC90, the concentrations at which 50% and 90% inhibition are achieved, are determined using GraphPad Prism software. Aliquots of cells are also saved for RNA isolation, cDNA synthesis, and PCR amplification for sequencing analysis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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