1. Membrane Transporter/Ion Channel
  2. Calcium Channel
    Na+/Ca2+ Exchanger
  3. SM-6586

SM-6586 

Cat. No.: HY-19062
Handling Instructions

SM-6586 is a calcium channel antagonist and inhibitor of Na+/H+ and Na+/Ca2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.

For research use only. We do not sell to patients.

SM-6586 Chemical Structure

SM-6586 Chemical Structure

CAS No. : 103898-38-0

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Description

SM-6586 is a calcium channel antagonist and inhibitor of Na+/H+ and Na+/Ca2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.

In Vivo

In SM-6586-treated spontaneously hypertensive rats, the survival rate after bilateral common carotid artery ligation is higher, the brain water content is lower, and the ATP level is higher and lactate level. In focal ischemia models, the SM-treated group shows a reduction of T1 relaxation time. The brain water content is significantly decreased in the SM-treated group[1].

Molecular Weight

489.52

Formula

C₂₆H₂₇N₅O₅

CAS No.

103898-38-0

SMILES

O=C(C1=C(C)NC(C)=C(C2=NC(CN(C)CC3=CC=CC=C3)=NO2)C1C4=CC=CC([N+]([O-])=O)=C4)OC

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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SM-6586
Cat. No.:
HY-19062
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