1. GPCR/G Protein
  2. Adrenergic Receptor

Tiodazosin (Synonyms: BL-5111)

Cat. No.: HY-100255
Handling Instructions

Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist.

For research use only. We do not sell to patients.

Tiodazosin Chemical Structure

Tiodazosin Chemical Structure

CAS No. : 66969-81-1

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist.

IC50 & Target

alpha adrenergic receptor[1]

In Vitro

Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist. In the mesenteric artery, Tiodazosin produces a parallel shift to the right in the concentration response curves to norepinephrine. A Schild plot constructed from two concentrations of Tiodazosin results in a pA2 value of 8.66 and a slope equal to -0.99. Tiodazosin inhibits contraction to norepinephrine in the portal vein and the inhibition results in a nonparallel inhibition of the norepinephrine concentration-response curve with a marked depression of maximal norepinephrine response[1].

References
Cell Assay
[1]

Arteries and portal veins isolated male Wistar rats (150 to 300 g) are sued and prepared for in vitro studies. Vessels are incubated with appropriate concentrations of Tiodazosin, prazosin or phentolamine for one hour. Contractile responses to norepinephrine or potassium chloride are then repeated in the presence of Tiodazosin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

431.47

Formula

C₁₈H₂₁N₇O₄S

CAS No.

66969-81-1

SMILES

O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4=NN=C(SC)O4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Tiodazosin
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Tiodazosin

Cat. No.: HY-100255