1. GPCR/G Protein
  2. Adrenergic Receptor

Tiodazosin (Synonyms: BL-5111)

Cat. No.: HY-100255
Handling Instructions

Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist.

For research use only. We do not sell to patients.

Tiodazosin Chemical Structure

Tiodazosin Chemical Structure

CAS No. : 66969-81-1

Size Price Stock
1 mg USD 1690 Get quote
5 mg USD 2705 Get quote
10 mg USD 4328 Get quote

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist.

IC50 & Target

alpha adrenergic receptor[1]

In Vitro

Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist. In the mesenteric artery, Tiodazosin produces a parallel shift to the right in the concentration response curves to norepinephrine. A Schild plot constructed from two concentrations of Tiodazosin results in a pA2 value of 8.66 and a slope equal to -0.99. Tiodazosin inhibits contraction to norepinephrine in the portal vein and the inhibition results in a nonparallel inhibition of the norepinephrine concentration-response curve with a marked depression of maximal norepinephrine response[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3177 mL 11.5883 mL 23.1766 mL
5 mM 0.4635 mL 2.3177 mL 4.6353 mL
10 mM 0.2318 mL 1.1588 mL 2.3177 mL
*Please refer to the solubility information to select the appropriate solvent.
Cell Assay

Arteries and portal veins isolated male Wistar rats (150 to 300 g) are sued and prepared for in vitro studies. Vessels are incubated with appropriate concentrations of Tiodazosin, prazosin or phentolamine for one hour. Contractile responses to norepinephrine or potassium chloride are then repeated in the presence of Tiodazosin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight









Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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Cat. No.: HY-100255