1. GPCR/G Protein
  2. GNRH Receptor

Triptorelin (Synonyms: [DTrp6]-LH-RH)

Cat. No.: HY-12551 Purity: 98.44%
Data Sheet SDS Handling Instructions

Triptorelin is a GnRH agaonist shown to inhibit estradiol-induced cancer cell proliferation In vivo: (1) Triptorelin can improve the pregnancy rate by 12% to 15% in ewes6 and downregulate ovarian GnRHR-I expression of female rats, especially in late-growing follicles.

For research use only. We do not sell to patients.
Triptorelin Chemical Structure

Triptorelin Chemical Structure

CAS No. : 57773-63-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO $130 In-stock
1 mg $50 In-stock
5 mg $70 In-stock
10 mg $90 In-stock
25 mg $140 In-stock
50 mg $180 In-stock
100 mg $210 In-stock
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500 mg   Get quote  

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Description

Triptorelin is a GnRH agaonist shown to inhibit estradiol-induced cancer cell proliferation In vivo: (1) Triptorelin can improve the pregnancy rate by 12% to 15% in ewes6 and downregulate ovarian GnRHR-I expression of female rats, especially in late-growing follicles. (2) Triptorelin immunity blocked EET and UWT, inhibited uterine growth and development and enhance the expression levels s of ESR1, LHR, and FSHR proteins.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT02477566 Nanjing University In Vitro Fertilization|Polycystic Ovary Syndrome December 2014
NCT00090844 University of South Florida|National Cancer Institute (NCI) Breast Cancer|Hormone Changes|Drug Toxicity July 2004 Phase 2
NCT00124514 Children's Hospital Medical Center, Cincinnati|Watson Pharmaceuticals Systemic Lupus Erythematosus June 2003 Phase 2
NCT01467882 Debiopharm International SA Central Precocious Puberty April 2012 Phase 3
NCT01656161 Debiopharm International SA|Quintiles, Inc. Prostate Cancer July 2012 Phase 3
NCT00751790 Debiopharm International SA Prostatic Neoplasm July 2006 Phase 3
NCT01278290 Hospital de Niños R. Gutierrez de Buenos Aires Central Precocious Puberty|Sexual Precocity July 2010 Phase 4
NCT01753297 Ipsen Prostate Cancer December 2012 Phase 4
NCT01374087 Ipsen Prostate Cancer November 2011 Phase 2
NCT00564850 Ipsen Precocious Puberty October 2007 Phase 3
NCT00909844 Ipsen Precocious Puberty April 2008 Phase 3
NCT01257425 Ipsen Prostate Cancer December 2010 Phase 2
NCT01020448 Ipsen Prostate Cancer November 2009 Phase 3
NCT01715129 Ipsen Prostate Cancer January 2013 Phase 3
NCT00461916 Tehran University of Medical Sciences Infertility May 2005 Phase 4
NCT00415246 Ipsen Prostate Cancer November 2006 Phase 3
NCT00444639 Ipsen Prostate Cancer February 2007 Phase 2
NCT02102646 Herlev Hospital Prostate Cancer|Metabolic Syndrome|Hypogonadism|Fatty Liver April 2014 Phase 4
NCT00412022 National Cancer Institute, Naples|Second University of Naples Breast Cancer March 2004 Phase 3
NCT02005887 International Breast Cancer Study Group Breast Cancer Invasive Nos February 2014 Phase 2
NCT03115307 Tampere University Hospital Infertility, Female January 2017 Phase 4
NCT00066703 International Breast Cancer Study Group|National Cancer Institute (NCI)|Breast International Group Breast Cancer August 2003 Phase 3
NCT01764230 Masaryk University|Ministry of Health, Czech Republic Hodgkin Lymphoma|Hodgkin Disease January 2004
NCT02053779 Centre Hospitalier Universitaire Ibn Rochd Infertility March 2014 Phase 3
NCT02022228 Chenshiling|National Natural Science Foundation of China|Comprehensive Strategic Sciences Cooperation Projects of Guangdong Province and Chinese Academy|Guangzhou Science and Technology Program key projects|National Key Basic Research Development Plan of China|Nanfang Hospital of Southern Medical University Infertility and at High Risk of OHSS July 2012
NCT02113553 Armando Santoro, MD|Istituto Clinico Humanitas Breast Cancer May 2013 Phase 2
NCT01160315 Erasme University Hospital|Fonds National de la Recherche Scientifique|Ipsen Fertility Preservation|Alkylating Agents|Lymphoma July 2002 Phase 2|Phase 3
NCT03169166 American University of Beirut Medical Center Sterility|Infertility March 1, 2017 Phase 4
NCT00725491 Merck Sharp & Dohme Corp. Controlled Ovarian Stimulation May 2007 Phase 3
NCT02238366 Ipsen Prostate Cancer November 2013
NCT00311636 Gruppo Italiano Mammella (GIM)|National Cancer Institute (NCI) Breast Cancer September 2003 Phase 3
NCT02208986 Vietnam National University|Merck Sharp & Dohme Corp.|The Fertility Clinic, Skive Regional Hospital, Denmark|Faculty of Health, Aarhus University Denmark|University of Southern Denmark Normal Oocyte Donors August 2014
NCT00667069 UNICANCER|National Cancer Institute (NCI) Prostate Cancer December 2007 Phase 3
NCT02856048 Assistance Publique - Hôpitaux de Paris Cancer|Toxicity Due to Chemotherapy|Sarcoma|Osteosarcoma|Lymphoma|Ewing Sarcoma November 2016 Phase 2|Phase 3
NCT01942369 Ipsen Deep Infiltrating Endometriosis (DIE) September 2013
NCT00104741 UNICANCER|National Cancer Institute (NCI) Prostate Cancer July 2004 Phase 3
NCT00840944 Belgian Study Group for Pediatric Endocrinology Idiopathic Short Stature January 2008 Phase 4
NCT01714648 Elisha Hospital|Merck Sharp & Dohme Corp. Ovarian Hyperstimulation Syndrome November 2012 Phase 4
NCT01161563 Watson Pharmaceuticals Prostate Cancer July 2010 Phase 4
NCT02312089 Mansoura University Infertility December 2014 Phase 4
NCT02312076 Mansoura University Infertility December 2014 Phase 4
NCT01581359 Instituto de Investigacion Sanitaria La Fe Endometriosis|Infertility March 2012 Phase 4
NCT03039049 Centre Hospitalier Universitaire Ibn Rochd Infertility March 2014 Phase 3
NCT01973842 Aristotle University Of Thessaloniki|Eugonia IVF Unit, Athens, Greece Subfertility February 2014 Phase 2
NCT02620124 Turku University Hospital Infertility May 2013 Phase 4
NCT01873378 Azienda Ospedaliera S. Maria della Misericordia Uterine Myoma January 2013
NCT03118830 Cairo University Invitro Fertilization April 21, 2017 Phase 4
NCT00635258 Centro Ginecologia y Obstetricia.|University of Valencia Pregnancy|Embryo Implantation January 2004
NCT01125488 Taipei Veterans General Hospital, Taiwan Endometriosis March 2008 Phase 3
NCT02070198 Bioroma Female Infertility|Poor Responder December 2013 Phase 4
NCT00375687 Kaunas University of Medicine Prostate Cancer August 2005
NCT01007851 V.K.V. American Hospital, Istanbul Infertility September 2006 Phase 3
NCT02022241 Chenshiling|National Natural Science Foundation of China|Comprehensive Strategic Sciences Cooperation Projects of Guangdong Province and Chinese Academy|Guangzhou Science and Technology Program key projects|National Key Basic Research Development Plan of China|Nanfang Hospital of Southern Medical University Infertility and at High Risk of OHSS July 2012
NCT00516490 V.K.V. American Hospital, Istanbul Infertility September 2006
NCT00003734 St. Luke's Hospital, Ireland|National Cancer Institute (NCI) Prostate Cancer December 1998 Phase 3
NCT01468441 Fertility - Assisted Fertilization Center Infertility September 2011
NCT01638026 HaEmek Medical Center, Israel Infertility September 2012 Phase 4
NCT00659373 International Breast Cancer Study Group|National Cancer Institute (NCI)|Australia and New Zealand Breast Cancer Trials Group|Cancer and Leukemia Group B Breast Cancer|Fatigue|Sleep Disorders December 2007 Phase 3
NCT02825290 Sheba Medical Center Embryo Transfer|Luteal Support July 2016 Phase 4
NCT03192527 Alphamab Jilin Co., Ltd. Infertility, Female June 2017 Phase 1
NCT00003026 European Organisation for Research and Treatment of Cancer - EORTC Prostate Cancer April 1997 Phase 3
NCT01732094 Universitair Ziekenhuis Brussel Infertility|Poor Ovarian Response July 2012 Phase 2
NCT01732068 Universitair Ziekenhuis Brussel Infertility|Poor Ovarian Response July 2012 Phase 2
NCT02681536 Woman's Health University Hospital, Egypt Infertility February 2016
NCT00633347 Instituto Valenciano de Infertilidad, IVI VALENCIA Infertility January 2007 Phase 4
NCT02201914 Bioroma Poor Responders|IVF|Clomiphene Citrate|GnRH Agonist|GnRH Antagonist January 2014 Phase 4
NCT01973816 University Hospital, Rouen Endometriosis November 2014 Phase 3
NCT00066807 International Breast Cancer Study Group|National Cancer Institute (NCI)|Breast International Group Breast Cancer August 2003 Phase 3
NCT02655146 Chong Qing Reproducive and Genetic Institute Infertility December 2015 Phase 4
NCT02400801 Universitaire Ziekenhuizen Leuven Endometriosis|Infertility June 2013
NCT00702520 Merck Sharp & Dohme Corp. Pregnancy|Neonates April 1, 2006
NCT00438217 University of Pisa Central Precocious Puberty Phase 4
NCT02635607 Chong Qing Reproducive and Genetic Institute|Merck Sharp & Dohme Corp. Infertility January 2016
NCT01969578 European Organisation for Research and Treatment of Cancer - EORTC Salivary Gland Cancer February 2015 Phase 2
NCT00417144 Eugonia Polycystic Ovary Syndrome|Ovarian Hyperstimulation Syndrome November 2003 Phase 4
NCT00417183 Eugonia Infertility September 2005 Phase 4
NCT00417066 Eugonia Infertility|Premature Ovarian Failure September 2003 Phase 4
NCT00194792 University of Washington|National Cancer Institute (NCI) Estrogen Receptor-positive Breast Cancer|HER2-negative Breast Cancer|Progesterone Receptor-positive Breast Cancer|Stage I Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer August 2005 Phase 2
NCT01402336 Seoul National University Hospital Infertility|Polycystic Ovary Syndrome June 2011 Phase 3
NCT02366494 Medical College of Wisconsin Prostate Cancer March 2015
NCT02346253 Stanford University|National Cancer Institute (NCI) Prostate Adenocarcinoma|Stage I Prostate Cancer|Stage IIA Prostate Cancer|Stage IIB Prostate Cancer|Stage III Prostate Cancer January 2015 Phase 1|Phase 2
NCT03071172 GeneScience Pharmaceuticals Co., Ltd.|Peking University Third Hospital|The First Affiliated Hospital with Nanjing Medical University|Women's Hospital School Of Medicine Zhejiang University|Xiangya Hospital of Central South University|Sixth Affiliated Hospital, Sun Yat-sen University|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|The First Affiliated Hospital of Anhui Medical University Ovarian Hyperstimulation Syndrome March 2017 Phase 3
NCT02940535 Navy General Hospital, Beijing Subfertility, Female|Ovulation Disorder December 2016
NCT02278185 University of Colorado, Denver Adenocarcinoma of the Prostate|Recurrent Prostate Cancer|Stage III Prostate Cancer|Stage IV Prostate Cancer November 11, 2015 Phase 2
NCT00066690 International Breast Cancer Study Group|Breast International Group|Cancer and Leukemia Group B|National Cancer Institute (NCI)|NSABP Foundation Inc|NCIC Clinical Trials Group|North Central Cancer Treatment Group|Southwest Oncology Group Estrogen Receptor Positive Breast Cancer|Progesterone Receptor Positive Tumor|Recurrent Breast Carcinoma|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer August 2003 Phase 3
NCT01500863 IVI Madrid Ovarian Hyperstimulation Syndrome November 2011 Phase 4
NCT00329797 Radiation Therapy Oncology Group|National Cancer Institute (NCI) Osteoporosis|Prostate Cancer March 2006 Phase 3
NCT02742675 Fudan University Prostate Cancer March 2016 Phase 2
NCT02685397 Sir Mortimer B. Davis - Jewish General Hospital Castration-resistant Prostate Cancer Patients With Oligometastases August 2016 Phase 2|Phase 3
NCT01546987 Radiation Therapy Oncology Group|National Cancer Institute (NCI)|NRG Oncology Prostate Cancer May 2012 Phase 3
NCT00936390 Radiation Therapy Oncology Group|National Cancer Institute (NCI)|NRG Oncology Prostate Cancer September 2009 Phase 3
NCT02715232 Medical University of Vienna Gender Dysphoria February 6, 2017 Phase 4
NCT00055731 UNICANCER|National Cancer Institute (NCI) Prostate Cancer November 2002 Phase 3
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References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 0.7625 mL 3.8126 mL 7.6251 mL
5 mM 0.1525 mL 0.7625 mL 1.5250 mL
10 mM 0.0763 mL 0.3813 mL 0.7625 mL
References
M.Wt

1311.45

Formula

C₆₄H₈₂N₁₈O₁₃

CAS No.

57773-63-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Triptorelin
Cat. No.:
HY-12551
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