1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Tropodifene

Tropodifene (Synonyms: Tropaphen)

Cat. No.: HY-U00313
Handling Instructions

Tropodifene (Tropaphen) is an α-Adrenergic receptor inhibitor.

For research use only. We do not sell to patients.

Tropodifene Chemical Structure

Tropodifene Chemical Structure

CAS No. : 15790-02-0

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Description

Tropodifene (Tropaphen) is an α-Adrenergic receptor inhibitor.

IC50 & Target

α-Adrenergic[1]

In Vivo

Tropaphen has a beneficial effect on hypertension. The therapeutic effect of this preparation is more constant in diseases accompanied by spasm of the peripheral vessels. Tropaphen has a very marked adrenolytic and vasodilator action. It greatly lowers the tone of the peripheral vessels. The preparation is effective starting with a dose of 0.1 mg/kg. After injection of the drug in a dose of 0.25 mg/kg, a considerable and gradually progressive decrease in the perfusion pressure takes place. The pressure falls by 30-35% and remained at a low level for 90-100 min. With a dose of tropaphen of 0.5 mg/kg, the perfusion pressure falls by 40-45% and remains low for 120 min or more. Strong vasodilatation is also observed after injection of tropaphen into intact rabbits[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

407.50

Formula

C₂₅H₂₉NO₄

CAS No.

15790-02-0

SMILES

O=C(O[[email protected]]1C[[email protected]](N2C)CC[[email protected]]2C1)C(C3=CC=CC=C3)CC4=CC=C(OC(C)=O)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[1]

Rabbits[1]

The drug is injected intravenously into rabbits. Experiments on the isolated ears of the rabbits are carried out by the Kravkov--Pisemskii method. The effect of tropaphen on the ear vessels of the intact rabbit is judged by the changes in the temperature of the ear. The temperature is measured by means of an electrothermometer, the detector of which is fixed to the internal surface of the ear. The dilation of the auricular vessels is also examined under the microscope, observations being made on the lumen of the marginal artery and vein[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

TropodifeneTropaphenAdrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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