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Referencia número: HY-144340

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Antitumor agent-43

Antitumor agent-43 (Compound 4B) is a potent antitumor agent, with an IC₅₀of 0.5 µM for (T-24 cell). Antitumor agent-43 (Compound 4B) induces cell cycle arrest at G2/M phase.

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No. CAS: 2766035-37-2
Fòrmula: C₁₆H₈N₂O₃
Peso molecular:276.25

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Antitumor agent-43 Chemical Structure

No. CAS: 2766035-37-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Antitumor agent-43 (Compound 4B) is a potent antitumor agent, with an IC₅₀of 0.5 µM for (T-24 cell). Antitumor agent-43 (Compound 4B) induces cell cycle arrest at G2/M phase^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	1.3 μM Compound: 4B	Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 35092899]
MGC-803	IC₅₀	1.1 μM Compound: 4B	Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 35092899]
SK-OV-3	IC₅₀	8.9 μM Compound: 4B	Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 35092899]
T-24	IC₅₀	0.5 μM Compound: 4B	Antiproliferative activity against human T24 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human T24 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 35092899]
WI-38	IC₅₀	14.8 μM Compound: 4B	Antiproliferative activity against human WI-38 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human WI-38 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 35092899]

In Vitro

Antitumor agent-43 towards T-24, MGC80-3, SK-OV-3, HepG2 cells with IC₅₀of 0.5, 1.1, 8.9 and 1.3µM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antitumor agent-43 effectively inhibits tumor growth (49.5%) in a mouse xenograft model bearing T-24. ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2766035-37-2
Peso molecular 276.25
Fòrmula C₁₆H₈N₂O₃
SMILES

O=C1C2=NC=CC3=C([N+]([O-])=O)C=CC(C4=C1C=CC=C4)=C23
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Lan-Shan Liao, et al. One-pot synthesis of oxoaporphines as potent antitumor agents and investigation of their mechanisms of actions. Eur J Med Chem [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Chemical Information
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Antitumor agent-43

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