1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Definition:

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

References:

[1]. D Park, et al. Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2. J Biol Chem. 1992 Aug 15;267(23):16048-55. [Content Brief]

[2]. E Tall, et al. Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs. Biochemistry. 1997 Jun 10;36(23):7239-48. [Content Brief]

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