2',5'-phosphodiesterase 12

Definition:

Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells.

References:

[1]. Michael A Estrella, et al. Crystal Structure of Human Nocturnin Catalytic Domain. Sci Rep. 2018 Nov 2;8(1):16294. [Content Brief]

[2]. Joanna Rorbach, et al. PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria. Nucleic Acids Res. 2011 Sep 1;39(17):7750-63. [Content Brief]

[3]. Kazuishi Kubota, et al. Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon. J Biol Chem. 2004 Sep 3;279(36):37832-41. [Content Brief]

[4]. Jesper Buchhave Poulsen, et al. Human 2'-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover. Nucleic Acids Res. 2011 May;39(9):3754-70. [Content Brief]

[5]. Edgar R Wood, et al. The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors. J Biol Chem. 2015 Aug 7;290(32):19681-96. [Content Brief]

[6]. Jesper B Poulsen, et al. Characterization of human phosphodiesterase 12 and identification of a novel 2'-5' oligoadenylate nuclease - The ectonucleotide pyrophosphatase/phosphodiesterase 1. Biochimie. 2012 May;94(5):1098-107. [Content Brief]

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