2-aminoethanethiol dioxygenase

Definition:

Plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate. Catalyzes the oxidation of cysteamine (2-aminoethanethiol) to hypotaurine. Catalyzes the oxidation of regulators of G-protein signaling 4 (RGS4) and 5 (RGS5) and interleukin-32 (IL32).

References:

[1]. Norma Masson, et al. Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants. Science. 2019 Jul 5;365(6448):65-69. [Content Brief]

[2]. John E Dominy Jr, et al. Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase. J Biol Chem. 2007 Aug 31;282(35):25189-98. [Content Brief]

[3]. Yifan Wang, et al. Characterization of the nonheme iron center of cysteamine dioxygenase and its interaction with substrates. J Biol Chem. 2020 Aug 14;295(33):11789-11802. [Content Brief]

[4]. Yifan Wang, et al. Cofactor Biogenesis in Cysteamine Dioxygenase: C-F Bond Cleavage with Genetically Incorporated Unnatural Tyrosine. Angew Chem Int Ed Engl. 2018 Jul 2;57(27):8149-8153. [Content Brief]

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