3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

Definition:

Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis. Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2). Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol. Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation. Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase.; [Isoform 3]: Does not have enzymatic activities toward E1 and DHT.

References:

[1]. R Breitling, et al. 17beta-hydroxysteroid dehydrogenase type 7--an ancient 3-ketosteroid reductase of cholesterogenesis. Mol Cell Endocrinol. 2001 Jan 22;171(1-2):199-204. [Content Brief]

[2]. Päivi Härkönen, et al. Sex hormone metabolism in prostate cancer cells during transition to an androgen-independent state. J Clin Endocrinol Metab. 2003 Feb;88(2):705-12. [Content Brief]

[3]. Zrinka Marijanovic, et al. Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. Mol Endocrinol. 2003 Sep;17(9):1715-25. [Content Brief]

[4]. Svea Törn, et al. Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7. Biochem Biophys Res Commun. 2003 May 23;305(1):37-45. [Content Brief]

[5]. Silvia Taramino, et al. Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts. Biochim Biophys Acta. 2010 Nov;1801(11):1232-7. [Content Brief]

[6]. Edith Bellavance, et al. Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. J Med Chem. 2009 Dec 10;52(23):7488-502. [Content Brief]

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