5,6-dihydroxyindole-2-carboxylic acid oxidase

Definition:

Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).

References:

[1]. Eimear E Kenny, et al. Melanesian blond hair is caused by an amino acid change in TYRP1. Science. 2012 May 4;336(6081):554. [Content Brief]

[2]. Caroline Rooryck, et al. Oculocutaneous albinism with TYRP1 gene mutations in a Caucasian patient. Pigment Cell Res. 2006 Jun;19(3):239-42. [Content Brief]

[3]. Dimitre R Simeonov, et al. DNA variations in oculocutaneous albinism: an updated mutation list and current outstanding issues in molecular diagnostics. Hum Mutat. 2013 Jun;34(6):827-35. [Content Brief]

[4]. Xuelei Lai, et al. Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9812-9815. [Content Brief]

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