A disintegrin and metalloproteinase with thrombospondin motifs 9

Definition:

Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.

References:

[1]. Sawako Yoshina, et al. Identification of a novel ADAMTS9/GON-1 function for protein transport from the ER to the Golgi. Mol Biol Cell. 2012 May;23(9):1728-41. [Content Brief]

[2]. Robert P T Somerville, et al. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. J Biol Chem. 2003 Mar 14;278(11):9503-13. [Content Brief]

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