Amyloidosis, Finnish type
Definition:
Amyloidosis, Finnish type (Meretoja syndrome) is an autosomal dominant form of systemic amyloidosis caused by a mutation in the gelsolin gene. It is characterized by lattice corneal dystrophy, progressive cranial neuropathy and systemic amyloid deposits.
References:
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[1]. A de la Chapelle, et al. Familial amyloidosis, Finnish type: G654----a mutation of the gelsolin gene in Finnish families and an unrelated American family. Genomics. 1992 Jul;13(3):898-901. [Content Brief]
[2]. C P Maury, et al. Finnish hereditary amyloidosis is caused by a single nucleotide substitution in the gelsolin gene. FEBS Lett. 1990 Dec 10;276(1-2):75-7. [Content Brief]
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