Anaplastic lymphoma kinase (ALK)

Definition:

Anaplastic lymphoma kinase (ALK) is a Receptor protein tyrosine kinase (rPTK), a member of the insulin receptor superfamily. ALK was first described in 1994 as the NPM-ALK fusion protein that is expressed in the majority of anaplastic large-cell lymphomas.

References:

[1]. Robert Roskoski Jr, et al. Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition. Pharmacol Res. 2013 Feb;68(1):68-94. [Content Brief]

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