APC membrane recruitment protein 2

Definition:

Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.

References:

[1]. Astrid S Pfister, et al. Amer2 protein is a novel negative regulator of Wnt/β-catenin signaling involved in neuroectodermal patterning. J Biol Chem. 2012 Jan 13;287(3):1734-41. [Content Brief]

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