B-cell receptor-associated protein 31

Definition:

Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40. In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2. May be involved in CASP8-mediated apoptosis.

References:

[1]. W G Annaert, et al. Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. J Cell Biol. 1997 Dec 15;139(6):1397-410. [Content Brief]

[2]. Takushi Namba, et al. BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites. Sci Adv. 2019 Jun 12;5(6):eaaw1386. [Content Brief]

[3]. M Nguyen, et al. Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria. Mol Cell Biol. 2000 Sep;20(18):6731-40. [Content Brief]

[4]. Yuichi Wakana, et al. Bap31 is an itinerant protein that moves between the peripheral endoplasmic reticulum (ER) and a juxtanuclear compartment related to ER-associated Degradation. Mol Biol Cell. 2008 May;19(5):1825-36. [Content Brief]

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