B-lymphocyte antigen CD20

Definition:

B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.

References:

[1]. Haidong Li, et al. Store-operated cation entry mediated by CD20 in membrane rafts. J Biol Chem. 2003 Oct 24;278(43):42427-34. [Content Brief]

[2]. T F Tedder, et al. The B cell surface molecule B1 is functionally linked with B cell activation and differentiation. J Immunol. 1985 Aug;135(2):973-9. [Content Brief]

[3]. J K Bubien, et al. Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. J Cell Biol. 1993 Jun;121(5):1121-32. [Content Brief]

[4]. Maria J Polyak, et al. CD20 homo-oligomers physically associate with the B cell antigen receptor. Dissociation upon receptor engagement and recruitment of phosphoproteins and calmodulin-binding proteins. J Biol Chem. 2008 Jul 4;283(27):18545-52. [Content Brief]

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