Basic helix-loop-helix domain-containing protein USF3

Definition:

Involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties.

References:

[1]. Ying Ni, et al. Germline compound heterozygous poly-glutamine deletion in USF3 may be involved in predisposition to heritable and sporadic epithelial thyroid carcinoma. Hum Mol Genet. 2017 Jan 15;26(2):243-257. [Content Brief]

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