Benign familial neonatal seizure

Definition:

Benign familial neonatal seizure (BFNS) is a benign epilepsy syndromes with autosomal dominant inheritance. They are a group of epilepsies which have a primary genetic background, usually no structural brain abnormalities and most of them have a benign course without additional neurological symptoms. BFNS are caused by loss-of-function mutations in the two genes KCNQ2 and KCNQ3 encoding the voltage-gated K+ channels.

References:

[1]. Anne T Berg, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. [Content Brief]

[2]. John C Mulley, et al. Proposed genetic classification of the "benign" familial neonatal and infantile epilepsies. Epilepsia. 2011 Mar;52(3):649-50. [Content Brief]

[3]. K Dedek, et al. Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12272-7. [Content Brief]

[4]. Yunxiang Liao, et al. Molecular correlates of age-dependent seizures in an inherited neonatal-infantile epilepsy. Brain. 2010 May;133(Pt 5):1403-14. [Content Brief]

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