Beta-1,4-galactosyltransferase 5

Definition:

Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (By similarity). Essential for extraembryonic development during early embryogenesis (By similarity).

References:

[1]. Toshiyuki Yamaji, et al. Establishment of HeLa cell mutants deficient in sphingolipid-related genes using TALENs. PLoS One. 2014 Feb 3;9(2):e88124. [Content Brief]

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