Beta-1,4-galactosyltransferase 6

Definition:

Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity).

References:

[1]. Toshiyuki Yamaji, et al. Establishment of HeLa cell mutants deficient in sphingolipid-related genes using TALENs. PLoS One. 2014 Feb 3;9(2):e88124. [Content Brief]

[2]. S Chatterjee, et al. Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase from human kidney. J Biol Chem. 1992 Apr 5;267(10):7148-53. [Content Brief]

[3]. S Chatterjee, et al. UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes. Biochim Biophys Acta. 1987 Jan 20;923(1):136-42. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.