Beta-1,4-galactosyltransferase 6

Definition

Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity).

References:

[1]. Toshiyuki Yamaji, et al. Establishment of HeLa cell mutants deficient in sphingolipid-related genes using TALENs. PLoS One. 2014 Feb 3;9(2):e88124. [Content Brief]

[2]. S Chatterjee, et al. Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase from human kidney. J Biol Chem. 1992 Apr 5;267(10):7148-53. [Content Brief]

[3]. S Chatterjee, et al. UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes. Biochim Biophys Acta. 1987 Jan 20;923(1):136-42. [Content Brief]

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