Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

Definition:

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation.

References:

[1]. Gopalkrishna Sreejit, et al. The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (β2M) affecting antigen presentation function of macrophage. PLoS Pathog. 2014 Oct 30;10(10):e1004446. [Content Brief]

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