Beta-adrenergic receptor kinase 1

Definition:

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light.

References:

[1]. Adel I Aziziyeh, et al. Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. Cell Signal. 2009 Jul;21(7):1207-17. [Content Brief]

[2]. Peter D Yim, et al. Airway smooth muscle photorelaxation via opsin receptor activation. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L82-L93. [Content Brief]

[3]. Christina S Pao, et al. Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylation. Biochemistry. 2009 Aug 4;48(30):7325-33. [Content Brief]

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