Betaine--homocysteine S-methyltransferase 1

Definition:

Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.

References:

[1]. N S Millian, et al. Human betaine-homocysteine methyltransferase is a zinc metalloenzyme. Arch Biochem Biophys. 1998 Aug 1;356(1):93-8. [Content Brief]

[2]. T A Garrow, et al. Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase. J Biol Chem. 1996 Sep 13;271(37):22831-8. [Content Brief]

[3]. A P Breksa 3rd, et al. Recombinant human liver betaine-homocysteine S-methyltransferase: identification of three cysteine residues critical for zinc binding. Biochemistry. 1999 Oct 19;38(42):13991-8. [Content Brief]

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