Bifunctional polynucleotide phosphatase/kinase

Definition

Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.

References:

[1]. F Karimi-Busheri, et al. Molecular characterization of a human DNA kinase. J Biol Chem. 1999 Aug 20;274(34):24187-94. [Content Brief]

[2]. R Daniel Aceytuno, et al. Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex. Nucleic Acids Res. 2017 Jun 2;45(10):6238-6251. [Content Brief]

[3]. Christine Anne Koch, et al. Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV. EMBO J. 2004 Oct 1;23(19):3874-85. [Content Brief]

[4]. Rajam S Mani, et al. Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining. J Biol Chem. 2010 Nov 26;285(48):37619-29. [Content Brief]

[5]. A Jilani, et al. Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage. J Biol Chem. 1999 Aug 20;274(34):24176-86. [Content Brief]

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