Bile salt-activated lipase

Definition:

Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins.

References:

[1]. H Tanaka, et al. Purification and characterization of bovine pancreatic bile salt-activated lipase. J Biochem. 1999 May;125(5):883-90. [Content Brief]

[2]. D Y Hui, et al. Lipoamidase activity in normal and mutagenized pancreatic cholesterol esterase (bile salt-stimulated lipase). Biochem J. 1993 Apr 1;291 ( Pt 1)(Pt 1):65-9. [Content Brief]

[3]. Matthew J Kolar, et al. Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry. 2016 Aug 23;55(33):4636-41. [Content Brief]

[4]. Xunjun Xiao, et al. A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis. J Biol Chem. 2016 Oct 28;291(44):23224-23236. [Content Brief]

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