Biogenesis of lysosome-related organelles complex 1 subunit 2

Definition:

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May play a role in cell proliferation.

References:

[1]. Jing Pu, et al. BORC, a multisubunit complex that regulates lysosome positioning. Dev Cell. 2015 Apr 20;33(2):176-88. [Content Brief]

[2]. Subba Rao Gangi Setty, et al. BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles. Mol Biol Cell. 2007 Mar;18(3):768-80. [Content Brief]

[3]. Zhaoqing Wang, et al. Characterization of Ceap-11 and Ceap-16, two novel splicing-variant-proteins, associated with centrosome, microtubule aggregation and cell proliferation. J Mol Biol. 2004 Oct 8;343(1):71-82. [Content Brief]

[4]. Marta Starcevic, et al. Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1). J Biol Chem. 2004 Jul 2;279(27):28393-401. [Content Brief]

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