Bone morphogenetic protein 1

Definition:

Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation.; [Isoform BMP1-3]: Plays an important role in bone repair by acting as a coactivator of BMP7.

References:

[1]. Lovorka Grgurevic, et al. Bone morphogenetic protein (BMP)1-3 enhances bone repair. Biochem Biophys Res Commun. 2011 Apr 29;408(1):25-31. [Content Brief]

[2]. Jun Wang, et al. Proteinase bone morphogenetic protein 1, but not tolloid-like 1, plays a dominant role in maintaining periodontal homeostasis. J Periodontol. 2021 Jul;92(7):1018-1029. [Content Brief]

[3]. Cyril Anastasi, et al. BMP-1 disrupts cell adhesion and enhances TGF-β activation through cleavage of the matricellular protein thrombospondin-1. Sci Signal. 2020 Jul 7;13(639):eaba3880. [Content Brief]

[4]. Elsa-Noah N'Diaye, et al. Extracellular BMP1 is the major proteinase for COOH-terminal proteolysis of type I procollagen in lung fibroblasts. Am J Physiol Cell Physiol. 2021 Feb 1;320(2):C162-C174. [Content Brief]

[5]. Tamara Rosell-García, et al. Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain. J Biol Chem. 2019 Jul 19;294(29):11087-11100. [Content Brief]

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