BRCA1-associated protein

Definition:

Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

References:

[1]. W Liu, et al. Nuclear transport of human DDB protein induced by ultraviolet light. J Biol Chem. 2000 Jul 14;275(28):21429-34. [Content Brief]

[2]. Sharon A Matheny, et al. Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. Nature. 2004 Jan 15;427(6971):256-60. [Content Brief]

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