BRCA2 and CDKN1A-interacting protein

Definition

During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).

References:

[1]. Xiangbing Meng, et al. Inhibition of G1 to S cell cycle progression by BCCIP beta. Cell Cycle. 2004 Mar;3(3):343-8. [Content Brief]

[2]. S C Huhn, et al. Regulation of spindle integrity and mitotic fidelity by BCCIP. Oncogene. 2017 Aug 17;36(33):4750-4766. [Content Brief]

[3]. Xiangbing Meng, et al. BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1. Cell Cycle. 2004 Nov;3(11):1457-62. [Content Brief]

[4]. Huimei Lu, et al. BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage. Nucleic Acids Res. 2007;35(21):7160-70. [Content Brief]

[5]. Huimei Lu, et al. The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. Mol Cell Biol. 2005 Mar;25(5):1949-57. [Content Brief]

[6]. T Ono, et al. TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase. J Biol Chem. 2000 Oct 6;275(40):31145-54. [Content Brief]

生物医学辞典

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