BRCA2-interacting transcriptional repressor EMSY

Definition:

Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. Mediates ligand-dependent transcriptional activation by nuclear hormone receptors.

References:

[1]. Luke Hughes-Davies, et al. EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell. 2003 Nov 26;115(5):523-35. [Content Brief]

[2]. Shivani Garapaty, et al. Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. J Biol Chem. 2009 Mar 20;284(12):7542-52. [Content Brief]

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