Bromo adjacent homology domain-containing 1 protein

Definition:

Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3.

References:

[1]. Hélène Bierne, et al. Human BAHD1 promotes heterochromatic gene silencing. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13826-31. [Content Brief]

[2]. Alice Lebreton, et al. A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response. Science. 2011 Mar 11;331(6022):1319-21. [Content Brief]

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