Brunner syndrome

Definition:

Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. It is caused by a monoamine oxidase A (MAOA) deficiency, which leads to an excess of monoamines in the brain, such as serotonin, dopamine, and epinephrine.

References:

[1]. H G Brunner, et al. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science. 1993 Oct 22;262(5133):578-80. [Content Brief]

[2]. H G Brunner, et al. MAOA deficiency and abnormal behaviour: perspectives on an association. Ciba Found Symp. 1996;194:155-64; discussion 164-7. [Content Brief]

[3]. H-Hilger Ropers, et al. X-linked mental retardation. Nat Rev Genet. 2005 Jan;6(1):46-57. [Content Brief]

[4]. Ian W Craig, et al. The importance of stress and genetic variation in human aggression. Bioessays. 2007 Mar;29(3):227-36. [Content Brief]

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