C-X-C chemokine receptor type 1

Definition:

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

References:

[1]. B B Damaj, et al. Physical association of Gi2alpha with interleukin-8 receptors. J Biol Chem. 1996 May 31;271(22):12783-9. [Content Brief]

[2]. W E Holmes, et al. Structure and functional expression of a human interleukin-8 receptor. Science. 1991 Sep 13;253(5025):1278-80. [Content Brief]

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