C-X-C chemokine receptor type 2

Definition:

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

References:

[1]. B B Damaj, et al. Physical association of Gi2alpha with interleukin-8 receptors. J Biol Chem. 1996 May 31;271(22):12783-9. [Content Brief]

[2]. P M Murphy, et al. Cloning of complementary DNA encoding a functional human interleukin-8 receptor. Science. 1991 Sep 13;253(5025):1280-3. [Content Brief]

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