Calcium-activated chloride channel regulator 2

Definition:

Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.

References:

[1]. M Abdel-Ghany, et al. The breast cancer beta 4 integrin and endothelial human CLCA2 mediate lung metastasis. J Biol Chem. 2001 Jul 6;276(27):25438-46. [Content Brief]

[2]. Che J Connon, et al. The quantification of hCLCA2 and colocalisation with integrin beta4 in stratified human epithelia. Acta Histochem. 2005;106(6):421-5. [Content Brief]

[3]. A D Gruber, et al. Tumorigenicity of human breast cancer is associated with loss of the Ca2+-activated chloride channel CLCA2. Cancer Res. 1999 Nov 1;59(21):5488-91. [Content Brief]

[4]. S A Bustin, et al. Expression of the Ca2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer. DNA Cell Biol. 2001 Jun;20(6):331-8. [Content Brief]

[5]. Che J Connon, et al. Gene expression and immunolocalisation of a calcium-activated chloride channel during the stratification of cultivated and developing corneal epithelium. Cell Tissue Res. 2006 Jan;323(1):177-82. [Content Brief]

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