Calmodulin regulator protein PCP4

Definition:

Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls. For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways.

References:

[1]. Xu Wang, et al. PEP-19 modulates calcium binding to calmodulin by electrostatic steering. Nat Commun. 2016 Nov 23;7:13583. [Content Brief]

[2]. Xu Wang, et al. The calmodulin regulator protein, PEP-19, sensitizes ATP-induced Ca2+ release. J Biol Chem. 2013 Jan 18;288(3):2040-8. [Content Brief]

[3]. Quinn K Kleerekoper, et al. PEP-19, an intrinsically disordered regulator of calmodulin signaling. J Biol Chem. 2009 Mar 20;284(12):7455-64. [Content Brief]

[4]. François Mouton-Liger, et al. PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-δ activation in mouse models of Down syndrome. J Comp Neurol. 2011 Oct 1;519(14):2779-802. [Content Brief]

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