Carboxypeptidase Z

Definition:

Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.

References:

[1]. L Song, et al. Cloning and expression of human carboxypeptidase Z, a novel metallocarboxypeptidase. J Biol Chem. 1997 Apr 18;272(16):10543-50. [Content Brief]

[2]. S E Reznik, et al. Carboxypeptidases from A to z: implications in embryonic development and Wnt binding. Cell Mol Life Sci. 2001 Nov;58(12-13):1790-804. [Content Brief]

[3]. Xuemo Fan, et al. Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary adenomas and normal human pituitary. J Histochem Cytochem. 2002 Nov;50(11):1509-16. [Content Brief]

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