Caspase-9

Definition:

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).; [Isoform 2]: Lacks activity is an dominant-negative inhibitor of caspase-9.

References:

[1]. Sonja Blasche, et al. The E. coli effector protein NleF is a caspase inhibitor. PLoS One. 2013;8(3):e58937. [Content Brief]

[2]. Jean-Bernard Denault, et al. Engineered hybrid dimers: tracking the activation pathway of caspase-7. Mol Cell. 2006 Aug;23(4):523-33. [Content Brief]

[3]. Ting Peng, et al. Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases. Mol Cell. 2022 May 19;82(10):1806-1820.e8. [Content Brief]

[4]. Yaxin Liu, et al. Calmodulin Binding Activates Chromobacterium CopC Effector to ADP-Riboxanate Host Apoptotic Caspases. mBio. 2022 Jun 28;13(3):e0069022. [Content Brief]

[5]. Scott J Eron, et al. Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms. Structure. 2017 Jan 3;25(1):27-39. [Content Brief]

[6]. Deepak Raina, et al. c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. J Biol Chem. 2005 Mar 25;280(12):11147-51. [Content Brief]

[7]. S M Srinivasula, et al. Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis. Cancer Res. 1999 Mar 1;59(5):999-1002. [Content Brief]

[8]. Davina Twiddy, et al. Caspase-7 is directly activated by the approximately 700-kDa apoptosome complex and is released as a stable XIAP-caspase-7 approximately 200-kDa complex. J Biol Chem. 2006 Feb 17;281(7):3876-88. [Content Brief]

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