Cathepsin B

Definition:

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis.

References:

[1]. A Ritonja, et al. Amino acid sequence of human liver cathepsin B. FEBS Lett. 1985 Feb 11;181(1):169-72. [Content Brief]

[2]. Rong Guo, et al. Inhibition of MEPE cleavage by Phex. Biochem Biophys Res Commun. 2002 Sep 13;297(1):38-45. [Content Brief]

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